期刊论文详细信息
| Journal of the Brazilian Chemical Society | |
| Simple method for fast deprotection of nucleosides by triethylamine-catalyzed methanolysis of acetates in aqueous medium | |
| Meier, Lidiane1 Baldissera, Rodrigo A. M.1 Sá, Marcus Mandolesi1 Monteiro, Gustavo C.1 Universidade Federal de Santa Catarina, Florianópolis, Brazil1 | |
| 关键词: nucleosides; triethylamine-catalyzed transesterification; microwave-assisted synthesis; deacetylation; | |
| DOI : 10.1590/S0103-50532010000500013 | |
| 学科分类：化学（综合） | |
| 来源: SciELO | |
 PDF
|
|
【 摘 要 】
A straightforward methodology for deacetylation of protected ribonucleosides was developed based on triethylamine-catalyzed solvolysis in aqueous methanol. Reactions are completed in a few minutes under microwave irradiation and the free nucleosides are obtained in high yield after simple evaporation of volatiles. Other important features include the involvement of readily available reagents and the compatibility with diverse functional groups, which make this process very attractive for broad application.
【 授权许可】
Unknown
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201912050581003ZK.pdf | 213KB |  download |
878987797
028-85220240
