Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA

Journal of the Brazilian Chemical Society

Afzal Shah¹  Rumana Qureshi¹  Asad M. Khan¹  Rasheed A Khera¹  Farzana L. Ansari¹ 

[1] ,Quaid-i-Azam University Department of Chemistry Islamabad,Paksitan

关键词: cyclic voltammetry;    UV-Vis;    DNA;    chalcone;    binding constant;   

DOI  :  10.1590/S0103-50532010000300008

来源: SciELO

【 摘 要 】

The electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one (ferrocenylone) and its interaction with DNA was studied by a glassy carbon electrode using cyclic voltammetry (CV) technique. The results from CV were supported by UV-Visible spectroscopy performed under the similar conditions. The positive peak potential shift in CV and the bathochromic shift in the UV-Vis absorption spectra suggested an intercalative mode of binding. The binding constant (K = 1.39 ± 0.02 × 10(4) mol-1 L) and the binding site size (0.53 bp) were obtained from voltammetric data which leads to a standard Gibbs free energy change (ΔGº= -RT lnK) of -23.64 kJ mol-1 and hence indicated the spontaneity of the binding interaction. The values of binding constants obtained from UV-Vis absorption and CV measurements, 1.26 ± 0.01 × 10(4) and 1.39 ± 0.02 × 10(4) mol-1 L respectively, were in close agreement.

【 授权许可】

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