Asymmetric transfer hydrogenation of ketones in aqueous solution catalyzed by rhodium(III) complexes with C2-symmetric fluorene-ligands containing chiral (1R,2R)-cyclohexane-1,2-diamine

Journal of the Brazilian Chemical Society

Rubén Montalvo-gonzález¹  Daniel Chávez¹  Gerardo Aguirre¹  Miguel Parra-hake¹  Ratnasamy Somanathan¹ 

[1] ,Instituto Tecnológico de Tijuana Centro de Graduados e Investigación ,México

关键词: bis(sulfonamide) ligands;    RhIII(Cp*) complexes;    asymmetric transfer hydrogenation;   

DOI  :  10.1590/S0103-50532010000300005

来源: SciELO

【 摘 要 】

Two C2-symmetric bis(sulfonamide) ligands containing fluorene-chiral (1R,2R)-cyclohexane-1,2-diamine were complexed to RhIII(Cp*) and used as catalyst to reduce aromatic ketones. The corresponding chiral secondary alcohols were obtained in 87-100% ee and 85-99% yield, under asymmetric transfer hydrogenation (ATH) conditions using aqueous sodium formate as the hydride source. With acetophenone, 94% ee and 86-97% yield was achieved with substrate/catalyst (S/C) ratio of 10,000.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License