Asymmetric transfer hydrogenation of ketones in aqueous solution catalyzed by rhodium(III) complexes with C2-symmetric fluorene-ligands containing chiral (1R,2R)-cyclohexane-1,2-diamine

Journal of the Brazilian Chemical Society

Montalvo-González, Rubén¹  Instituto Tecnológico de Tijuana, México¹  Aguirre, Gerardo¹  Chávez, Daniel¹  Universidad Autónoma de Nayarit, México¹  Parra-Hake, Miguel¹  Somanathan, Ratnasamy¹ 

关键词: bis(sulfonamide) ligands;    RhIII(Cp*) complexes;    asymmetric transfer hydrogenation;   

DOI  :  10.1590/S0103-50532010000300005

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Two C2-symmetric bis(sulfonamide) ligands containing fluorene-chiral (1R,2R)-cyclohexane-1,2-diamine were complexed to RhIII(Cp*) and used as catalyst to reduce aromatic ketones. The corresponding chiral secondary alcohols were obtained in 87-100% ee and 85-99% yield, under asymmetric transfer hydrogenation (ATH) conditions using aqueous sodium formate as the hydride source. With acetophenone, 94% ee and 86-97% yield was achieved with substrate/catalyst (S/C) ratio of 10,000.

【 授权许可】

Unknown