Vibrational and thermal properties of crystalline topiramate

Journal of the Brazilian Chemical Society

Diniz M. Sena Jr.²  Paulo T. C. Freire²  Josué M. Filho¹  Francisco E. A. Melo¹  Fenelon M. Pontes¹  Elson Longo¹  Odair P. Ferreira¹  Oswaldo L. Alves¹ 

[1] ,Universidade Regional do CaririCrato CE ,Brazil

关键词: organic crystals;    vibrational spectra;    X-ray diffraction;    thermodynamic properties;   

DOI  :  10.1590/S0103-50532008000800022

来源: SciELO

【 摘 要 】

Topiramate, a powerful anticonvulsant drug, was investigated by X-ray diffractometry, FT-Raman, FT-IR, TGA and DTA techniques as well as by DFT calculations. From this study it was possible to tentatively assign most of the normal vibrational modes of the crystal. Thermal analysis from room temperature to 900 ºC shows that the material does not present any structural phase transition and that the decomposition occurs in a two-step exothermic process.

【 授权许可】

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