Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide

Journal of the Brazilian Chemical Society

Marcos A. P. Martins¹  Dayse N. Moreira¹  Clarissa P. Frizzo¹  Kelvis Longhi¹  Nilo Zanatta¹  Helio G. Bonacorso¹ 

[1] ,Universidade Federal de Santa Maria Departamento de Química Santa Maria RS ,Brazil

关键词: pyrazoline;    enones;    cyanoacetohydrazide;    cyclocondensation;   

DOI  :  10.1590/S0103-50532008000700019

来源: SciELO

【 摘 要 】

The synthesis of thirteen 1-cyanoacetyl-5-hydroxy-5-halomethyl-1H-4,5-dihydropyrazoles from the reaction of 4-alkoxy-3-alken-2-ones [R³C(O)C(R²)=C(R¹)(OR), where R³ = CF3, CCl3, CHCl2, CO2Et; R² = H, Me; R¹ = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. In order to show the versatility of using the 1-cyanoacetyl-substituted pyrazoles as important building blocks in organic synthesis, some attempts to obtain pyrazole derivatives also are described.

【 授权许可】

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