Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide

Journal of the Brazilian Chemical Society

Zanatta, Nilo¹  Bonacorso, Helio G.¹  Martins, Marcos A. P.¹  Moreira, Dayse N.¹  Frizzo, Clarissa P.¹  Longhi, Kelvis¹  Universidade Federal de Santa Maria, Santa Maria, Brazil¹ 

关键词: pyrazoline;    enones;    cyanoacetohydrazide;    cyclocondensation;   

DOI  :  10.1590/S0103-50532008000700019

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The synthesis of thirteen 1-cyanoacetyl-5-hydroxy-5-halomethyl-1H-4,5-dihydropyrazoles from the reaction of 4-alkoxy-3-alken-2-ones [R3C(O)C(R2)=C(R1)(OR), where R3 = CF3, CCl3, CHCl2, CO2Et; R2 = H, Me; R1 = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. In order to show the versatility of using the 1-cyanoacetyl-substituted pyrazoles as important building blocks in organic synthesis, some attempts to obtain pyrazole derivatives also are described.

【 授权许可】

Unknown