Palladium polypyridyl complexes: synthesis, characterization, DNA interaction and biological activity on Leishmania (L.) mexicana

Journal of the Brazilian Chemical Society

Maribel Navarro²  Adelmo Betancourt¹  Clara Hernández¹  Edgar Marchán¹ 

[1] ,Instituto Venezolano de Investigaciones Científicas Centro de Química Caracas,Venezuela

关键词: palladium complexes;    polypyridyl;    Leishmania (L.) mexicana;   

DOI  :  10.1590/S0103-50532008000700018

来源: SciELO

【 摘 要 】

This paper describes the search for new potential chemotherapeutic agents based on transition metal complexes with planar ligands. In this study, palladium polypyridyl complexes were synthesized and characterized by elemental analysis, NMR, UV-VIS and IR spectroscopies. The interaction of the complexes with DNA was also investigated by spectroscopic methods. All metal-to-ligand charge transfer (MLCT) bands of the palladium polypyridyl complexes exhibited hypochromism and red shift in the presence of DNA. The binding constant and viscosity data suggested that the complexes [PdCl2(phen)] and [PdCl2(phendiamine)] interact with DNA by electrostatic forces. Additionally, these complexes induced an important leishmanistatic effect on L. (L.) mexicana promastigotes at the final concentration of 10 µmol L-1 in 48 h.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License