Chemical constituents of the underground stem bark of Duguetia furfuracea (Annonaceae)

Journal of the Brazilian Chemical Society

Denise B. Da Silva¹  Elaine C. O. Tulli¹  Walmir S. Garcez²  Evandro A. Nascimento²  João M. De Siqueira¹ 

[1] ,Universidade Federal do Mato Grosso do Sul Departamento de Farmácia Campo Grande MS ,Brazil

关键词: alkaloids;    Annonaceae;    aporphines;    duguetine beta-N-oxide;    Duguetia furfuracea;    sesquiterpenoids;   

DOI  :  10.1590/S0103-50532007000800017

来源: SciELO

【 摘 要 】

In the present investigation the underground parts of Duguetia furfuracea (Annonaceae) were used to conduct a phytochemical study that included the brine shrimp (Artemia salina) lethality bioassay. The substances (-)-duguetine beta-N-oxide, (-)-duguetine, dicentrinone, (-)-N-methyltetrahydropalmatine, and (+)-N-methylglaucine were isolated from the alkaloid extract of the bark of the underground stem, and the ureide allantoin was also isolated by precipitation from the ethanol extract of the wood of the underground stem. A fresh volatile oil and a nonpolar extract were also obtained from the underground stem bark. The substances 2,4,5-trimethoxystyrene, a-gurjunene, aromadendrene, bicyclogermacrene, (E)-methylisoeugenol, and alpha-asarone were isolated from the fresh volatile oil and polycarpol, beta-caryophyllene oxide, 2,4,5-trimethoxystyrene, a-asarone, and asaraldehyde were obtained from the petroleum ether extract. The present study describes for the first time the alkaloid (-)-duguetine beta-N-oxide and the occurrence of (-)-N-methyltetrahydropalmatine and (+)-N-methylglaucine in the family Annonaceae. All extracts were active in the brine shrimp lethality bioassay.

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