Chemical constituents of the underground stem bark of Duguetia furfuracea (Annonaceae)

Journal of the Brazilian Chemical Society

Silva, Denise B. da¹  Nascimento, Evandro A.¹  Siqueira, João M. de¹  Garcez, Walmir S.¹  Tulli, Elaine C. O.¹  Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil¹  Universidade Federal de Uberlândia, Uberlândia, Brazil¹ 

关键词: alkaloids;    Annonaceae;    aporphines;    duguetine b-N-oxide;    Duguetia furfuracea;    sesquiterpenoids;   

DOI  :  10.1590/S0103-50532007000800017

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

In the present investigation the underground parts of Duguetia furfuracea (Annonaceae) were used to conduct a phytochemical study that included the brine shrimp (Artemia salina) lethality bioassay. The substances (-)-duguetine b-N-oxide, (-)-duguetine, dicentrinone, (-)-N-methyltetrahydropalmatine, and (+)-N-methylglaucine were isolated from the alkaloid extract of the bark of the underground stem, and the ureide allantoin was also isolated by precipitation from the ethanol extract of the wood of the underground stem. A fresh volatile oil and a nonpolar extract were also obtained from the underground stem bark. The substances 2,4,5-trimethoxystyrene, a-gurjunene, aromadendrene, bicyclogermacrene, (E)-methylisoeugenol, and a-asarone were isolated from the fresh volatile oil and polycarpol, b-caryophyllene oxide, 2,4,5-trimethoxystyrene, a-asarone, and asaraldehyde were obtained from the petroleum ether extract. The present study describes for the first time the alkaloid (-)-duguetine b-N-oxide and the occurrence of (-)-N-methyltetrahydropalmatine and (+)-N-methylglaucine in the family Annonaceae. All extracts were active in the brine shrimp lethality bioassay.

【 授权许可】

Unknown