期刊论文详细信息
Journal of the Brazilian Chemical Society
Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
Mauro V. De Almeida1  Joana Darc S. Chaves1  Ana Paula Soares Fontes1  Eloi T. César2  Marcel Gielen2 
[1] ,Universidade Federal de Juiz de Fora Departamento de Química Juiz de Fora MG ,Brazil
关键词: platinum(II) complexes;    1;    2-phenylenediamine;    N-benzyl ethylenediamine;    picoline;    cancer;   
DOI  :  10.1590/S0103-50532006000700011
来源: SciELO
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【 摘 要 】

This work describes the synthesis and characterization of eleven new platinum(II) complexes having ligands derived from 1,2-phenylenediamine, N-benzyl ethylenediamine and 2- or 4-picoline. The complexes were prepared in satisfactory yields by reaction of K2[PtCl4] with the appropriate ligand. The cytotoxic pre-screening of one of these complexes in seven human cancer cell lines showed that this compound is much less active than cisplatin.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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