期刊论文详细信息
Journal of the Brazilian Chemical Society | |
Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives | |
Almeida, Mauro V. de1  Chaves, Joana Darc S.1  Gielen, Marcel1  César, Eloi T.1  Colégio de Aplicação João XXIII, Juiz de Fora, Brazil1  Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil1  Free University of Brussels, Brussels, Belgium1  Fontes, Ana Paula Soares1  | |
关键词: platinum(II) complexes; 1; 2-phenylenediamine; N-benzyl ethylenediamine; picoline; cancer; | |
DOI : 10.1590/S0103-50532006000700011 | |
学科分类:化学(综合) | |
来源: SciELO | |
【 摘 要 】
This work describes the synthesis and characterization of eleven new platinum(II) complexes having ligands derived from 1,2-phenylenediamine, N-benzyl ethylenediamine and 2- or 4-picoline. The complexes were prepared in satisfactory yields by reaction of K2[PtCl4] with the appropriate ligand. The cytotoxic pre-screening of one of these complexes in seven human cancer cell lines showed that this compound is much less active than cisplatin.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050580040ZK.pdf | 238KB | download |