Microwave assisted synthesis of 6-Substituted aminopurine analogs in water

Journal of the Brazilian Chemical Society

Guirong Qu¹  Suhui Han¹  Zhiguang Zhang¹  Mingwei Geng¹  Feng Xue¹ 

[1] ,Henan Normal University College of Chemistry and Environmental Science ,China

关键词: amination;    6-substituted aminopurine analogs;    nucleophilic substitution;    microwave irradiation;    amines;   

DOI  :  10.1590/S0103-50532006000500015

来源: SciELO

【 摘 要 】

Microwave assisted amination of 6-chloropurine derivatives with various amines in water resulted in a "green chemistry" protocol for the preparation of 6-substituted aminopurine analogs in very good yields. Using a simply modified microwave oven with the refluxing apparatus, the amination of the 6-chloro in the purine structure occurred smoothly. 19 known and 16 unknown 6-substituted aminopurine analogs were prepared through nucleophilic aromatic substitution with simple filtration or column chromatography.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License