Microwave assisted synthesis of 6-Substituted aminopurine analogs in water

Journal of the Brazilian Chemical Society

Henan Normal University, China¹  Zhang, Zhiguang¹  Geng, Mingwei¹  Xue, Feng¹  Han, Suhui¹  Qu, Guirong¹ 

关键词: amination;    6-substituted aminopurine analogs;    nucleophilic substitution;    microwave irradiation;    amines;   

DOI  :  10.1590/S0103-50532006000500015

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Microwave assisted amination of 6-chloropurine derivatives with various amines in water resulted in a "green chemistry" protocol for the preparation of 6-substituted aminopurine analogs in very good yields. Using a simply modified microwave oven with the refluxing apparatus, the amination of the 6-chloro in the purine structure occurred smoothly. 19 known and 16 unknown 6-substituted aminopurine analogs were prepared through nucleophilic aromatic substitution with simple filtration or column chromatography.

【 授权许可】

Unknown