Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis

Journal of the Brazilian Chemical Society

Simone S. Simões²  Everaldo P. Medeiros²  Edvaldo N. Gaião²  Wellington S. Lyra²  Pablo N. T. Moreira²  Mario C. U. Araújo²  Edvan C. Silva²  Valberes B. Nascimento¹ 

[1] ,Universidade Federal da Paraíba CCEN Departamento de QuímicaJoão Pessoa PB ,Brazil

关键词: flow injection analysis;    spectrophotometry;    pharmaceuticals;    metronidazole;    nitrite;   

DOI  :  10.1590/S0103-50532006000300028

来源: SciELO

【 摘 要 】

A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from common ingredients accompanying the drug.

【 授权许可】

CC BY   
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