Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis

Journal of the Brazilian Chemical Society

Lyra, Wellington S.¹  Araújo, Mario C. U.¹  Silva, Edvan C.¹  Nascimento, Valberes B.¹  Universidade Federal Rural de Pernambuco, Recife, Brazil¹  Gaião, Edvaldo N.¹  Moreira, Pablo N. T.¹  Simões, Simone S.¹  Medeiros, Everaldo P.¹  Universidade Federal da Paraíba, João Pessoa, Brazil¹ 

关键词: flow injection analysis;    spectrophotometry;    pharmaceuticals;    metronidazole;    nitrite;   

DOI  :  10.1590/S0103-50532006000300028

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from common ingredients accompanying the drug.

【 授权许可】

Unknown