Electrospray ionization mass spectrometry screening of piperidine alkaloids from Senna spectabilis (Fabaceae) extracts: fast identification of new constituents and co-metabolites

Journal of the Brazilian Chemical Society

Marcos Pivatto²  Antônio E. M. Crotti¹  Norberto P. Lopes¹  Ian Castro-gamboa²  Amanda De Rezende²  Cláudio Viegas Jr.²  Maria Claudia M. Young¹  Maysa Furlan²  Vanderlan S. Bolzani² 

[1] ,Universidade Estadual Paulista Instituto de Química Araraquara SP ,Brazil

关键词: Senna spectabilis;    piperidine alkaloids;    metabolomic profile;    electrospray;    tandem mass spectrometry;   

DOI  :  10.1590/S0103-50532005000800023

来源: SciELO

【 摘 要 】

The fragmentation pattern of a homologous series of piperidine alkaloids isolated from S. spectabilis was investigated using electrospray ionization tandem mass spectrometry (ESI-MS/MS). The ESI-MS and ESI-MS/MS analyses of EtOH extracts and fractions from flowers and fruits of S. spectabilis allowed to elucidate the structures of four new compounds. The identification of these co-metabolites, based on the fragmentation patterns of previously isolated compounds, and further confirmed by accurate mass spectrometry defines this technique as a powerful tool to determine the "metabolomic profile" of species which has pharmacological importance.

【 授权许可】

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