Isoprenoid compounds from Euphorbia portlandica. X-ray structure of lupeportlandol, a new lupane triterpene

Journal of the Brazilian Chemical Society

Ana M. Madureira²  Maria Teresa Duarte¹  Maria Fátima M. Piedade¹  José R. Ascenso¹  Maria-josé U. Ferreira² 

[1] ,Universidade de Lisboa Faculdade de Farmácia Centro de Estudos de Ciências FarmacêuticasLisboa,Portugal

关键词: Euphorbia portlandica;    triterpenes;    steroids;    lupane;    X-ray diffraction;   

DOI  :  10.1590/S0103-50532004000500021

来源: SciELO

【 摘 要 】

Phytochemical survey of the Me2CO extracts of the whole dried plant Euphorbia portlandica led to the isolation of a new pentacyclic triterpene alcohol, with the lupane skeleton, named lupeportlandol. Its structure was established as 3alpha-hydroxy-19alphaH-lup-20(29)-ene. The known pentacyclic triterpene glutinol and the steroid b-sitostenone were also isolated. The characterization of the new compound and its acetylated derivative was based on spectroscopic methods and an X-ray diffraction analysis. Lupeportlandol acetate was inactive in cytotoxicity assays in vitro against three human tumor cell lines: MCF-7 (breast cancer), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer).

【 授权许可】

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