Isoprenoid compounds from Euphorbia portlandica. X-ray structure of lupeportlandol, a new lupane triterpene

Journal of the Brazilian Chemical Society

Ferreira, Maria-José U.¹  Duarte, Maria Teresa¹  Piedade, Maria Fátima M.¹  Instituto Superior Técnico, Lisboa, Portugal¹  Madureira, Ana M.¹  Ascenso, José R.¹  Universidade de Lisboa, Lisboa, Portugal¹ 

关键词: Euphorbia portlandica;    triterpenes;    steroids;    lupane;    X-ray diffraction;   

DOI  :  10.1590/S0103-50532004000500021

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Phytochemical survey of the Me2CO extracts of the whole dried plant Euphorbia portlandica led to the isolation of a new pentacyclic triterpene alcohol, with the lupane skeleton, named lupeportlandol. Its structure was established as 3a-hydroxy-19aH-lup-20(29)-ene. The known pentacyclic triterpene glutinol and the steroid b-sitostenone were also isolated. The characterization of the new compound and its acetylated derivative was based on spectroscopic methods and an X-ray diffraction analysis. Lupeportlandol acetate was inactive in cytotoxicity assays in vitro against three human tumor cell lines: MCF-7 (breast cancer), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer).

【 授权许可】

Unknown