Synthesis of new 1,2,4-oxadiazoles carrying (1'S,2'S)-t-butyloxycarbonyl-1-amino-2- methyl-1-butyl and (1'S)-t-butyloxycarbonyl-1'-amino-1'-ethyl groups at C-5

Journal of the Brazilian Chemical Society

Vanildo Martins L. Braga²  Sebastião J. De Melo²  Rajendra M. Srivastava¹  Emerson Peter Da S. Falcão² 

[1] ,Universidade Federal de Pernambuco Departamento de Antibióticos Recife PE ,Brazil

关键词: chiral drugs;    1;    2;    4-oxadiazoles;    arylamidoximes;    isoleucine;    alanine;    antiinflammatory;    antipyretic;   

DOI  :  10.1590/S0103-50532004000400025

来源: SciELO

【 摘 要 】

A facile and efficient synthesis of 3-aryl-5-[(1S)-t-butyloxycarbonyl-1-amino-(2 S)-methyl-1-butyl)]-1,2,4-oxadiazoles 4a-f and 3-phenyl-5-[(1S)-t-butyloxycarbonyl-1-amino-1-ethyl]-1,2,4 -oxadiazole 6 starting from arylamidoximes, N-t-Boc-L-isoleucine and N-t- Boc-L-alanine is decribed. The structures of the intermediates and final compounds have been deduced from spectroscopic data.

【 授权许可】

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