期刊论文详细信息
Journal of the Brazilian Chemical Society | |
Synthesis of new 1,2,4-oxadiazoles carrying (1'S,2'S)-t-butyloxycarbonyl-1-amino-2- methyl-1-butyl and (1'S)-t-butyloxycarbonyl-1'-amino-1'-ethyl groups at C-5 | |
Srivastava, Rajendra M.1  Universidade Federal de Pernambuco, Recife, Brazil1  Falcão, Emerson Peter da S.1  Braga, Vanildo Martins L.1  Melo, Sebastião J. de1  | |
关键词: chiral drugs; 1; 2; 4-oxadiazoles; arylamidoximes; isoleucine; alanine; antiinflammatory; antipyretic; | |
DOI : 10.1590/S0103-50532004000400025 | |
学科分类:化学(综合) | |
来源: SciELO | |
【 摘 要 】
A facile and efficient synthesis of 3-aryl-5-[(1S)-t-butyloxycarbonyl-1-amino-(2 S)-methyl-1-butyl)]-1,2,4-oxadiazoles 4a-f and 3-phenyl-5-[(1S)-t-butyloxycarbonyl-1-amino-1-ethyl]-1,2,4 -oxadiazole 6 starting from arylamidoximes, N-t-Boc-L-isoleucine and N-t- Boc-L-alanine is decribed. The structures of the intermediates and final compounds have been deduced from spectroscopic data.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050579575ZK.pdf | 181KB | download |