期刊论文详细信息
Journal of the Brazilian Chemical Society | |
A complete model of the Plasmodium falciparum bifunctional enzyme dihydrofolate reductase-thymidylate synthase: a model to design new antimalarials | |
Tanos C. C. França1  André L. R. De Medeiros1  Edison C. P. Dos Santos1  Osvaldo A. Santos-filho1  José D. Figueroa-villar1  | |
[1] ,Instituto Militar de Engenharia Departamento de Química Rio de Janeiro RJ ,Brasil | |
关键词: malaria; homology modeling; DHFR-TS; optimized substrate transport; Plasmodium falciparum; | |
DOI : 10.1590/S0103-50532004000300019 | |
来源: SciELO | |
【 摘 要 】
We propose a theoretical model for pfDHFR-TS, which includes the 55 aminoacid residues ignored in the crystallographic model. The electrostatic potential calculation on the model surface revealed a continuous positive potential region between the two active sites, suggesting an optimized mechanism for dihydrofolate transport.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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