期刊论文详细信息
Journal of the Brazilian Chemical Society | |
A complete model of the Plasmodium falciparum bifunctional enzyme dihydrofolate reductase-thymidylate synthase: a model to design new antimalarials | |
França, Tanos C. C.1  Santos, Edison C. P. dos1  Medeiros, André L. R. de1  Figueroa-Villar, José D.1  Santos-Filho, Osvaldo A.1  Instituto Militar de Engenharia, Rio de Janeiro, Brasil1  | |
关键词: malaria; homology modeling; DHFR-TS; optimized substrate transport; Plasmodium falciparum; | |
DOI : 10.1590/S0103-50532004000300019 | |
学科分类:化学(综合) | |
来源: SciELO | |
【 摘 要 】
We propose a theoretical model for pfDHFR-TS, which includes the 55 aminoacid residues ignored in the crystallographic model. The electrostatic potential calculation on the model surface revealed a continuous positive potential region between the two active sites, suggesting an optimized mechanism for dihydrofolate transport.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050579550ZK.pdf | 498KB | download |