期刊论文详细信息
| Journal of the Brazilian Chemical Society | |
| A complete model of the Plasmodium falciparum bifunctional enzyme dihydrofolate reductase-thymidylate synthase: a model to design new antimalarials | |
| França, Tanos C. C.1 Santos, Edison C. P. dos1 Medeiros, André L. R. de1 Figueroa-Villar, José D.1 Santos-Filho, Osvaldo A.1 Instituto Militar de Engenharia, Rio de Janeiro, Brasil1 | |
| 关键词: malaria; homology modeling; DHFR-TS; optimized substrate transport; Plasmodium falciparum; | |
| DOI : 10.1590/S0103-50532004000300019 | |
| 学科分类：化学（综合） | |
| 来源: SciELO | |
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【 摘 要 】
We propose a theoretical model for pfDHFR-TS, which includes the 55 aminoacid residues ignored in the crystallographic model. The electrostatic potential calculation on the model surface revealed a continuous positive potential region between the two active sites, suggesting an optimized mechanism for dihydrofolate transport.
【 授权许可】
Unknown
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201912050579550ZK.pdf | 498KB |  download |
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