Evaluation of lipases in the desymmetrization of meso-exo-3,5-dihydroxymethylenetricyclo[5.2.1.0(2,6)]decane and the synthesis of chiral derivatives

Journal of the Brazilian Chemical Society

Valentim E. U Costa¹  Adriana R Pohlmann¹  Marli L. T. De Sordi¹ 

[1] ,Universidade Federal do Rio Grande do Sul Instituto de Química

关键词: lipases;    enzymatic catalysis;    desymmetrization;    chiral compounds;   

DOI  :  10.1590/S0103-50532004000100005

来源: SciELO

【 摘 要 】

meso-exo-3,5-dihydroxymethylenetricyclo[5.2.1.0(2,6)]decane was efficiently desymmetrized by the lipase from Pseudomonas cepacia (PS-C 'Amano' II) in vinyl acetate in high yields (93%) and with excellent enantiomeric excesses (ee > 99% by chiral GC). Chiral synthons for asymmetric synthesis were synthesized from this enantiopure compound.

【 授权许可】

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