Evaluation of lipases in the desymmetrization of meso-exo-3,5-dihydroxymethylenetricyclo[5.2.1.0(2,6)]decane and the synthesis of chiral derivatives

Journal of the Brazilian Chemical Society

Pohlmann, Adriana R¹  Costa, Valentim E. U¹  Universidade Federal do Rio Grande do Sul¹  Sordi, Marli L. T. de¹ 

关键词: lipases;    enzymatic catalysis;    desymmetrization;    chiral compounds;   

DOI  :  10.1590/S0103-50532004000100005

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

meso-exo-3,5-dihydroxymethylenetricyclo[5.2.1.0 2,6]decane was efficiently desymmetrized by the lipase from Pseudomonas cepacia (PS–C 'Amano' II) in vinyl acetate in high yields (93%) and with excellent enantiomeric excesses (ee > 99% by chiral GC). Chiral synthons for asymmetric synthesis were synthesized from this enantiopure compound.

【 授权许可】

Unknown