Preparation of aromatic geraniol analogues via a Cu(I)-mediated Grignard coupling

Journal of the Brazilian Chemical Society

J. Luis Paz¹  J. Augusto R. Rodrigues¹ 

[1] ,Universidade Estadual de Campinas Instituto de Química Campinas SP ,Brazil

关键词: allylic oxidation;    selenium dioxide;    homoallylic alcohols;    Grignard coupling;    2-geranylphenols;   

DOI  :  10.1590/S0103-50532003000600014

来源: SciELO

【 摘 要 】

Difunctional allylic terpenes are important synthetic building blocks. Functionalization of protected geranyl derivatives by SeO2/t-BuO2H adsorbed on SiO2 provides a convenient route to such compounds. The chosen protecting groups clearly influence the oxidation process. Also, an efficient synthesis of 2-geranylphenol derivatives via a Cu(I)-mediated Grignard coupling of 2-lithiophenols and geranyl substrates was developed.

【 授权许可】

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