Preparation of aromatic geraniol analogues via a Cu(I)-mediated Grignard coupling

Journal of the Brazilian Chemical Society

Universidade Estadual de Campinas, Campinas, Brazil¹  Paz, J. Luis¹  Rodrigues, J. Augusto R.¹ 

关键词: allylic oxidation;    selenium dioxide;    homoallylic alcohols;    Grignard coupling;    2-geranylphenols;   

DOI  :  10.1590/S0103-50532003000600014

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Difunctional allylic terpenes are important synthetic building blocks. Functionalization of protected geranyl derivatives by SeO2/t-BuO2H adsorbed on SiO2 provides a convenient route to such compounds. The chosen protecting groups clearly influence the oxidation process. Also, an efficient synthesis of 2-geranylphenol derivatives via a Cu(I)-mediated Grignard coupling of 2-lithiophenols and geranyl substrates was developed.

【 授权许可】

Unknown