LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation

Journal of the Brazilian Chemical Society

Andrea J. M. Maurin¹  Yassuko Iamamoto²  Norberto P. Lopes¹  John R. Lindsay-smith²  Pierina S. Bonato¹ 

[1] ,Universidade de São Paulo Faculdade de Ciências Farmacêuticas de Ribeirão Preto Departamento de Física e QuímicaRibeirão Preto SP ,Brazil

关键词: LC-MS-MS;    metabolism;    metalloporphyrin;    disopyramide;    albendazole;   

DOI  :  10.1590/S0103-50532003000200022

来源: SciELO

【 摘 要 】

In this paper we report the application of liquid chromatography-mass spectrometry (LC-MS-MS) to the identification of the products formed by oxidation of albendazole and disopyramide with metalloporphyrins in dichloroethane, using iodosylbenzene as an oxygen donor. Our results show that LC-MS-MS is a powerful tool to study the in vitro metabolism of drugs, allowing the identification of known and unknown metabolites. In addition, it was observed that the catalyst system used resulted in the formation of the same metabolites as obtained in vivo, although for disopyramide other products were also observed.

【 授权许可】

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