Persistence of hepatitis A virus antibodies after primary immunization and response to revaccination in children and adolescents with perinatal HIV exposure

Revista Paulista de Pediatria

Aída De Fátima Thomé Barbosa Gouvêa¹  Maria Isabel De Moraes Pinto¹  Maristela Miyamoto¹  Daisy Maria Machado¹  Silvana Duarte Pessoa¹  Fabiana Bononi Do Carmo¹  Suênia Cordeiro De Vasconcelos Beltrão¹  Regina Célia De Menezes Succi¹ 

关键词: HIV;    Adolescent and children;    Hepatitis A vaccine;    Immunossupression;    HIV;    Crianças e adolescentes;    Vacina de hepatite A;    Imunossupressão;   

DOI  :  10.1016/j.rpped.2014.09.005

来源: SciELO

【 摘 要 】

OBJECTIVE: To assess possible factors associated with the loss of antibodies to hepatitis A 7 years after the primary immunization in children of HIV-infected mothers and the response to revaccination in patients seronegative for hepatitis A. METHODS: Quantification of HAV antibodies by electrochemiluminescence was performed in 39 adolescents followed up at the Pediatric Aids Clinic of Federal University of São Paulo (Unifesp): 29 HIV-infected (HIV group) (median age: 12.8 years) and 10 HIV-exposed but non-infected (ENI group) (median age: 13.4 years). All of them received two doses of HAV vaccine (Havrix(r)) in 2002. RESULTS: The median age at primary immunization (PI) was 5.4 years for HIV group and 6.5 years for ENI group. All children, from both groups, had antibodies to HAV >20 mIU/mL after PI. Seven years later, the ENI group showed a median concentration of antibodies = 253.5 mIU/mL, while the HIV group = 113.0 mIU/mL (Mann-Whitney test, p=0.085). All ENI group and 23/29 (79.3%) from HIV group mantained HAV antibodies 7 years after PI. The levels of hepatitis A antibodies in the primary vaccination were the only factor independently associated with maintaining these antibodies for 7 years. The group that lost HAV seropositivity was revaccinated and 83.3% (5/6) responded with antibodies >20 mUI/mL. CONCLUSIONS: The antibodies levels acquired in the primary vaccination in the HIV group were the main factor associated with antibodies loss after HAV immunization.

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