Lipoprotein (a) and cardiovascular risk factors in children and adolescents

Revista Paulista de Pediatria

Ástrid Camêlo Palmeira¹  Adriana Amorim De F. Leal¹  Nathaly De Medeiros N. Ramos¹  José De Alencar F. Neto¹  Mônica Oliveira Da S. Simões¹  Carla Campos M. Medeiros¹ 

关键词: cardiovascular diseases;    obesity;    child;    adolescent;    lipoprotein(a);    enfermedades cardiovasculares;    obesidad;    niño;    adolescente;    lipoproteína (a);    doenças cardiovasculares;    obesidade;    criança;    adolescente;    lipoproteína(a);   

DOI  :  10.1590/S0103-05822013000400017

来源: SciELO

【 摘 要 】

OBJECTIVE: To review the relationship between lipoprotein (a) [Lp(a)] and other risk factors for cardiovascular disease (CVD) in children and adolescents. DATA SOURCES: This systematic review included studies from 2001 to 2011, a ten-year time period. Epidemiological studies with children and/or adolescents published in English, Portuguese or Spanish and fully available online were included. The searches were performed in Science Direct, PubMed/Medline, BVS (Biblioteca Virtual em Saúde) and Cochrane Library databases, using the following combination of key-words: "lipoprotein a" and "cardiovascular diseases" and "obesity". DATA SYNTHESIS: Overall, 672 studies were obtained but only seven were included. Some studies assessed the family history for CVD. In all of them, Lp(a) levels were increased in patients with family history for CVD. There was also a positive correlation between Lp(a) and LDL-cholesterol, total cholesterol, and apolipoprotein B levels, suggesting an association between Lp(a) levels and the lipid profile. CONCLUSIONS: The evidence that CVD may originate in childhood and adolescence leads to the need for investigating the risk factors during this period in order to propose earlier and possibly more effective interventions to reduce morbidity and mortality rates.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License