Effects of ropivacaine combined with morphine at 0.15 and 0.2 mg kg-1 in bitches undergoing epidural anesthesia

Acta Cirurgica Brasileira

Verônica Batista De Albuquerque¹  Marcelo Augusto De Araújo¹  Gabriel Thadeu Nogueira Martins Ferreira¹  Mariana Werneck Fonseca¹  André Moreira Martins Arruda¹  Lu Shichen¹  Valéria Nobre Leal De Souza Oliva¹ 

关键词: Analgesics;    Opioid;    Chromatography;    High Pressure Liquid;    Hydrocortisone;    Dogs;   

DOI  :  10.1590/S0102-8650201500300000010

来源: SciELO

【 摘 要 】

PURPOSE: To investigate cardiorespiratory effects and serum concentration of ropivacaine combined with morphine at different doses.METHODS: Sixteen healthy adult female dogs weighting 9.8±4.1 kg were included in the study. Twenty minutes after being premedicated with acepromazine and midazolam, the animals were randomly assigned to receive an epidural injection according to each group: RM0.15 = ropivacaine + morphine (0.15 mg kg-1) and RM0.2 = ropivacaine + morphine (0.2 mg kg-1). Variables recorded consisted of: heart rate and cardiac rhythm, respiratory rate, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, systolic, mean and diastolic arterial pressures, serum cortisol, plasma ropivacaine and morphine.RESULTS: SAP, MAP and DAP were significantly increased at TPR in RM0.15 but returned to normal values at the end of the procedure. Arterial pH was decreased in T30 and TESu in both groups and also returned to acceptable ranges at TR. Both PaO2 and PaCO2 were increased along the duration period of the epidural blockade (T30 and TESu) and returned to acceptable values at TR. Serum cortisol was lower at TB, T30 and TR when compared to TESu.CONCLUSION: The procedures were performed safely and minimal changes in cardiovascular and respiratory variables.

【 授权许可】

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