Effect of exercise on the maternal outcome in pregnancy of spontaneously hypertensive rats

Acta Cirurgica Brasileira

Renato Rocha¹  José Carlos Peraçoli¹  Gustavo Tadeu Volpato¹  Débora Cristina Damasceno¹  Kleber Eduardo De Campos¹ 

关键词: Exercise;    Hypertension;    Pregnancy;    Rats;    Inbred SHR;   

DOI  :  10.1590/S0102-8650201400150002

来源: SciELO

【 摘 要 】

PURPOSE:To evaluate the effect of exercise (swimming) on pregnancy in spontaneously hypertensive rats (SHR).METHODS: Thirty three pregnant female SHR were distributed into three groups (n=11 animals/group): SHR Control=non-exercised (sedentary); SHR Ex0 = exercised from day zero to day 20 of pregnancy; and SHR Ex7 = exercised from day 7 to 20 of pregnancy. Body weight and systolic blood pressure were indirectly measured during pregnancy. On gestational day 21, the rats were anaesthetized and uterine content was withdrawn for analysis of maternal reproductive outcome parameters and fetal development.RESULTS:The reduced blood pressure percentage was higher in SHR Ex0 and SHR Ex7 compared to SHR Control group. Weight gain was present in all pregnancy periods, but it was lower in SHR Ex7 than in SHR Control dams. The exercise increased the pre-implantation loss rate. The post-implantation loss rate was lower in SHR Ex0 group. SHR Ex7 group showed a significantly higher percentage of fetuses classified as small for gestational age as compared to others groups.CONCLUSION:The exercise contributed to lowering gestational blood pressure in SHR rats, but had a negative impact on the developing embryo.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License