Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats

Acta Cirurgica Brasileira

Cecília Maria De Carvalho Xavier Holanda¹  Delianne Azevedo Barbosa¹  Vanessa Fávero Demeda¹  Flora Tamires Moura Bandeira¹  Hilkéa Carla Souza De Medeiros¹  Kércia Regina Santos Gomes Pereira¹  Vanessa Santos De Arruda Barbosa¹  Aldo Cunha Medeiros¹ 

关键词: Annona;    Technetium Tc 99m Dimercaptosuccinic Acid;    Radiopharmaceuticals;    Biological Availability;    Rats;   

DOI  :  10.1590/S0102-86502014000300001

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the effect of hydroalcoholic extract of A. muricata on biodistribution of two radiopharmaceuticals: sodium phytate and dimercaptosuccinic acid (DMSA), both labeled with 99mtechnetium.METHODS: Twenty four Wistar rats were divided into two treated groups and two controls groups. The controls received water and the treated received 25mg/kg/day of A. muricata by gavage for ten days. One hour after the last dose, the first treated group received 99mTc-DMSA and the second sodium 99mTc-phytate (0.66MBq each group), both via orbital plexus. Controls followed the same protocol. Forty min later, all groups were sacrificed and the blood, kidney and bladder were isolated from the first treated group and the blood, spleen and liver isolated from the second treated group. The percentage of radioactivity per gram of tissue (%ATI/g) was calculated using a gamma counter.RESULTS: The statistical analysis showed that there was a statistically significant decrease (p<0.05) in the uptake of %ATI/g in bladder (0.11±0.01and1.60±0.08), kidney (3.52±0.51and11.84±1.57) and blood (0.15±0.01and 0.54±0.05) between the treated group and control group, respectively.CONCLUSION: The A. muricata hydroalcoholic extract negatively influenced the uptake of 99mTc-DMSA in bladder, kidney and blood of rats.

【 授权许可】

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