The ileum positively regulates hepatic regeneration in rats

Acta Cirurgica Brasileira

Aldo Cunha Medeiros¹  Ana Clara Batista Azevedo¹  Jéssica Mayara De Figueiredo Oséas¹  Mariana Davim Ferreira Gomes¹  Fernanda Gurgel De Oliveira¹  Keyla Borges Ferreira Rocha¹  Ítalo Medeiros Azevedo¹  Amália Cínthia Meneses Rêgo¹  Marília Daniela Ferreira Carvalho¹ 

关键词: Hepatectomy;    Liver;    Ileum;    Liver Regeneration;    Rats;   

DOI  :  10.1590/S0102-86502014000200004

来源: SciELO

【 摘 要 】

PURPOSE: To test the hypothesis that liver regeneration after partial hepatectomy can be influenced by the ileum.METHODS:Eighteen Wistar rats were distributed into groups of six animals: 1 - ileum resection+ hepatectomy 2/3; 2 - hepatectomy 2/3, and 3 - sham. Anesthesia with ketamine and xylazine i.p., aseptic technique, analgesia with meperidine (10mg/kg s.c.). On day 6, serum ALT, AST, alkaline phosphatase (AP) and albumin were measured. Liver regeneration and hepatocyte mitosis were quantified. Statistical analysis with ANOVA and Tukey tests, with significance p<0.05.RESULTS:In group hepatectomy+ileal resection, ALT, AST and AP were 180.6±24.9, 58.6±3.1 and 254.6±46.6 respectively. They were significantly higher than in the hepatectomy group, whose values were 126.0±16.5, 44.1±3.9 and 163.5±8.6, respectively (p<0.001). Albumin levels were not significantly different among groups. Liver regeneration in hepatectomy group (94.17%) was statistically higher (p<0.001) than in ileal resection+hepatectomy group (55.96%). In the latter group the mitosis of hepatocytes were significantly less frequent than in the hepatectomy group.CONCLUSION: The data confirm that the ileum positively influence on liver regeneration in rats undergoing hepatectomy.

【 授权许可】

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