Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1

Acta Cirurgica Brasileira

José Lacerda Brasileiro²  Celso Maschaschi Inoye¹  Ricardo Dutra Aydos¹  Iandara Schettert Silva¹  Gustavo Ribeiro Falcão¹  Guido Marks¹  Daniel Martins Pereira¹ 

[1] ,Federal University of Mato Grosso do Sul (UFMS) Department of Surgery Campo Grande MS ,Brazil

关键词: Ischemia;    Reperfusion;    Intestine;    Small;    Alprostadil;    Rats;   

DOI  :  10.1590/S0102-86502013001100004

来源: SciELO

【 摘 要 】

PURPOSE: To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1. METHODS: Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately. In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria. RESULTS: Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations. CONCLUSION: Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.

【 授权许可】

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