Systemic evaluation on ischemia and reperfusion injury of splanchnic organs in rats

Acta Cirurgica Brasileira

Nereide Freire Cerqueira¹  Carlos Alberto Hussni²  Winston Bonetti Yoshida¹  Carlos Roberto Padovani¹ 

[1] ,UNESP FMVZ Department of Veterinary Surgery and Anesthesiology,Brazil

关键词: Ischemia;    Reperfusion;    Intestine;    Small;    Shock;    Rats;    Isquemia;    Reperfusão;    Intestino Delgado;    Choque;    Ratos;   

DOI  :  10.1590/S0102-86502009000400008

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate hemodynamic and systemic changes during and after splanchnic ischemia and reperfusion (I/R). METHODS: Rats were divided into two groups: a) control: animals submitted to surgery, but not to I/R, treated with saline (5 ml/kg/h) for 150 min; b) group I/R: animals continuously infused with saline, and submitted to occlusion of the celiac trunk, superior mesenteric artery (SMA), and inferior mesenteric artery for 30 min, followed by a 120-min reperfusion. Mean arterial blood pressure (MABP), venous pressure, aortic and SMA blood flow, heart rate, esophageal temperature and hematocrit were evaluated. RESULTS: During reperfusion in I/R groups, there was a progressive decrease in MABP, aortic blood flow, SMA blood flow, heart rate and esophageal temperature; vein pressure and hematocrit remained unchanged during the experiment. CONCLUSION: The model of ischemia used causes systemic changes, which are evidenced by hypotension, decrease in mesenteric blood flow, heart rate and esophageal temperature.

【 授权许可】

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