Experimental ovarian transplantation on stomach for bone repair in ovariohysterectomized rabbits

Acta Cirurgica Brasileira

Gholam Reza Abedi²  Amir Sotoudeh¹  Ali Bazzazan¹  Amin Ganjai¹ 

[1] ,Islamic Azad University Science and Research Branch Faculty of Specialized Veterinary SciencesTehran,Iran

关键词: Hysterectomy;    Ovary;    Organ Transplantation;    Rabbits;   

DOI  :  10.1590/S0102-86502013000600002

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the bone repair process in ovariohysterectomized rabbit submitted to an ovarian transplant to stomach that may supplying some quantity of estrogen occurs to improve bone healing. METHODS: In 20 female rabbits three holes of 1, 2 and 3mm diameter in tibial shaft were made and after that all animals received OHE through a ventral incision and they were randomly divided into two groups of ten rabbits each. In group one, animals received one of their self-ovaries that transplanted on serosal layer of stomach and group two did not receive treatment. Animals were kept during bone healing for a period of 45 days and radiological, biochemical, biomechanical and histopathological evaluation. RESULTS: The tibial defects in group one healed completely after 45 days and had more callous than second group. There is significant difference between two groups after operation in 21, 28 and 35 days about estrogen, progesterone and phosphatase Alkaline. The maximum forces in group one, were significantly higher than that for the group two. CONCLUSION:Ovarian transplantation prevents the effects of ovariohysterectomized on bone healing of rabbit tibia, suggesting that unilateral transplanted ovaries can substitute for the action of ovaries on the skeleton in ovariohysterectomized animals.

【 授权许可】

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