Biochemical study of the effects of cilostazol in rats subjected to acute ischemia and reperfusion of hind limbs

Acta Cirurgica Brasileira

Sylvio Sebastião De Souza Júnior¹  Antonio Augusto Moreira Neto²  Aurelino Fernandes Schmidt Júnior¹  José Benedito Dias Lemos¹  Olavo Ribeiro Rodrigues¹ 

[1] ,UMC Department of Surgery Vascular Surgery DivisionMogi das Cruzes SP ,Brazil

关键词: Ischemia;    Reperfusion;    Urea;    Creatinine;    Myoglobin;    Rats;   

DOI  :  10.1590/S0102-86502013000500007

来源: SciELO

【 摘 要 】

PURPOSE: To investigate whether cilostazol has a protective effect on acute ischemia and reperfusion of hind limbs of rats through study of biochemical variables in blood and urine. METHODS: Forty six animals were randomized and divided into two groups. Group I received a solution of cilostazol (10 mg/Kg) and group II received saline solution 0.9% (SS) by orogastric tube after ligature of the abdominal aorta. After four hours of ischemia the animals were divided into four subgroups: group IA (Cilostazol): two hours of reperfusion. Group IIA (SS): two hours of reperfusion. Group IB (Cilostazol): six hours of reperfusion. Group IIB (SS) six hours of reperfusion. After the reperfusion period, was held to collect urine and blood for biochemical measurements. The biochemical parameters studied were: urea, creatinine, sodium, potassium and myoglobin in blood and urea, creatinine, myoglobin in urine. RESULTS: There was no statistically significant difference between groups. CONCLUSION: Cilostazol had no protective effect on ischemic acute reperfusion of hind limbs of rats in this model.

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