The effects of local nitroglycerin on the surgical delay procedure in prefabricated flaps by vascular implant in rats

Acta Cirurgica Brasileira

Jairo Zacchê De Sá¹  José Lamartine De Andrade Aguiar²  Adriana Ferreira Cruz¹  Alexandre Ricardo Pereira Schuler¹  José Ricardo Alves De Lima¹  Olga Martins Marques¹ 

[1] ,UFPE Postgraduate Program in Surgery Department of SurgeryRecife PE ,Brazil

关键词: Surgical Flaps;    Nitroglycerin;    Rats;    Retalhos Cirúrgicos;    Nitroglicerina;    Ratos;   

DOI  :  10.1590/S0102-86502012001200013

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the effect of local nitroglycerin on the viable area of a prefabricated flap for vascular implant in rats, and to investigate the surgical delay procedure. METHODS: A femoral pedicle was implanted under the skin of the abdominal wall in forty Wistar rats. The animals were divided into four groups of ten: group 1 - without surgical delay procedure and local nitroglycerin; group 2 - with surgical delay procedure, but without local nitroglycerin; group 3 - without surgical delay procedure, but with local nitroglycerin; and group 4 - with simultaneous surgical delay procedure and local nitroglycerin. The percentages of the viable areas, in relation to the total flap, were calculated using AutoCAD R 14. RESULTS: The mean percentage value of the viable area was 8.9% in the group 1. 49.4% in the group 2; 8.4% in the group 3 and 1.1% in the group 4. There was significant difference between groups 1 and 2 (p=0.005), 1 and 4 (p=0.024), 2 and 3 (p=0.003), 2 and 4 (p=0.001). These results support the hypothesis that the closure of the arterial venous channels is responsible for the phenomenon of surgical delay procedure. CONCLUSION: Local nitroglycerin did not cause an increase in the prefabricated viable flap area by vascular implantation and decreased the viable flap area that underwent delay procedures.

【 授权许可】

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