Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea

Acta Cirurgica Brasileira

Patrícia Veruska Ribeiro Barbosa Lemos²  José Luiz Martins¹  Sidney Pereira Pinto Lemos¹  Fernando Leandro Dos Santos¹  Sílvio Romero Gonçalves E Silva¹ 

[1] ,Sao Francisco Valley Federal University Department of Medicine ,Brazil

关键词: Pesticides;    Ethylenethiourea;    Liver;    Hematopoiesis;    Extramedullary;    Pregnancy;    Animal;    Animals;    Newborn;    Rats;    Praguicidas;    Etilenotiouréia;    Fígado;    Hematopoese Extramedular;    Prenhez;    Animais Recém-Nascidos;    Ratos;   

DOI  :  10.1590/S0102-86502012001200012

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate hepatic morphological-histological abnormalities in newborns from female rats exposed to ethylenethiourea. METHODS: A randomized study was conducted on fifty-five newborn Wistar rats were studied: 34 in the experimental group, whose mothers had been exposed to 1% ethylenethiourea; and 21 in the control group, whose mothers had received 0.9% physiological solution. The solution was administered via gavage on the 11th day of gestation. Cesarean section was performed on the 20th day of gestation. The newborns' livers were examined and any morphological-histological abnormalities were registered. The presence of megakaryocytes was quantified in 50 microscope fields, as the total number of these cells per mm². RESULTS: The entire experimental group presented abnormalities of embryonic formation, with musculoskeletal anomalies, digestive system anomalies, hepatic congestion and friability, hydrops and delayed intrauterine growth. The histopathological analysis showed that morphological-histological hepatic destructuring had occurred in all entire experimental with removal of the hepatic trabeculae and severe hepatic megakaryocytosis. The mean megakaryocyte density ranged from 107.9 to 114.2 per mm², and it was eight times greater than in the control group, thus characterizing a situation of extramedullary hematopoiesis. CONCLUSION: The fetal exposure to ethylenethiourea caused hepatic damage characterized by severe extramedullary hematopoiesis.

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