Effects of chitosan on healing and strength of colonic anastomosis in rats

Acta Cirurgica Brasileira

Bulent Citgez¹  Ahmet Nurettin Cengiz¹  Ismail Akgun¹  Mehmet Uludag¹  Gurkan Yetkin¹  Neslihan Bahat¹  Omer Ozcan¹  Nedim Polat¹  Adem Akcakaya¹  Oguzhan Karatepe² 

[1] ,Vakif University İstanbul ,Turkey

关键词: Chitosan;    Anastomosis;    Surgical;    Tensile Strength;    Wound Healing;    Rats;    Quitosana;    Anastomose Cirúrgica;    Resistência à Tração;    Cicatrização;    Ratos;   

DOI  :  10.1590/S0102-86502012001000007

来源: SciELO

【 摘 要 】

PURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.

【 授权许可】

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