Influence of arterial hypertension on colonic healing in rats

Acta Cirurgica Brasileira

Gilberto Luiz Ortolan¹  Maria De Lourdes Pessole Biondo-simões²  Giovani Marino Fávero¹  Daniel Fernandes¹  Mário Rodrigues Montemór Netto¹  Luiz Renato Olchanheski Jr¹ 

[1] ,PUCPR Department of Surgery

关键词: Wound Healing;    Colon;    Hypertension;    Rats;    Inbred SHR;    Cicatrização;    Cólon;    Hipertensão;    Ratos Endogâmicos SHR;   

DOI  :  10.1590/S0102-86502012000800001

来源: SciELO

【 摘 要 】

PURPOSE: Evaluation of colonic healing in spontaneously hypertensive rats. METHODS: Fifty male, young and inbred rats were used. Twenty-five Wistar Kyoto rats (WKY) as control and twenty-five spontaneously hypertensive rats (SHR) as an experimental group. Colotomy and bowel suture at 2.5 cm from the peritoneal reflection were performed. All animals were allocated randomly into sub-groups for review at the third, seventh and fourteenth days after surgery. We evaluated the concentration of angiotensin II, the burst pressure, epithelialization, the organization of the tunics of the bowel wall, inflammatory response and collagen deposition. RESULTS: The burst pressure, epithelialization, organization of the tunics and collagen deposition was not significant between groups. The inflammatory reaction was more intense in the control group on the third postoperative day (p=0.023) as the experimental group on the remaining time. CONCLUSION: Systemic arterial hypertension in rats did not influence significantly the healing process of colonic anastomoses.

【 授权许可】

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