Changes in the volume and histology of endometriosis foci in rats treated with copaiba oil (Copaiferalangsdorffii)

Acta Cirurgica Brasileira

João Nogueira Neto¹  Márcio Jorge De Souza Lindoso²  Laura Fernandes Coelho²  Rafael Antonio Freire Carvalho²  Taciana Gabrielle Pinheiro De Moura Rodrigues²  Ana Gisélia Portela De Araújo¹  Manuel João Batista Castelo Girão¹  Eduardo Schor¹ 

[1] ,UFMAMaranhao,Brazil

关键词: Phytotherapy;    Endometriosis;    Drug Therapy;    Rats;    Fitoterapia;    Endometriose;    Quimioterapia;    Ratos;   

DOI  :  10.1590/S0102-86502011000800005

来源: SciELO

【 摘 要 】

PURPOSE: The aim of this study was to analyze the changes that occur in rats with experimental endometriosis after treatment with copaiba oil. METHODS: Experimental endometriosis was induced in rats. The experimental group received copaiba oil (Copaiferalangsdorffii) orally (0.63 mg/day), and the control group received a 0.9% sodium chloride solution orally (1 ml/100 g of body weight/day). Both groups were treated with gavage for 14 days. After this period, the animals were euthanized, and the implant volume was calculated. The autologous transplants were removed, dyed with hematoxylin-eosin, and analyzed by light microscopy. RESULTS: The average final volumes were significantly different between the groups (p=0.007). There was a significant increase (p=0.012) between the initial and final volumes in the control group, whereas treatment with Copaiferalangsdorffii caused a marked reduction in endometrial growth over time (p=0.016). Histologically, 6/11 (55.00%) rats in the experimental group had a well-preserved epithelial layer, and 3 (45.00%) had mildly preserved epithelium. The control group had seven cases (58.30%) of well-preserved epithelial cells and five cases (41.70%) of mildly preserved epithelial cells (p>0.05). CONCLUSION: Copaiba oil (Copaiferalangsdorffii) appears to be a promising alternative treatment for endometriosis.

【 授权许可】

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