Effects of sildenafil on the viability of random skin flaps

Acta Cirurgica Brasileira

Sumara Marques Barral²  Ivana Duval Araujo²  Paula Vieira Teixeira Vidigal¹  Cláudio Alvarenga Campos Mayrink¹  Adriana Duval Araujo¹  Paulo Roberto Da Costa¹ 

[1] ,UFMG Department of Surgery Belo Horizonte MG ,Brazil

关键词: Wound Healing;    Surgical Flaps;    Cyclic GMP;    Nitric Oxide;    Rats;    Cicatrização de Feridas;    Retalhos Cirúrgicos;    GMP Cíclico;    Óxido Nítrico;    Ratos;   

DOI  :  10.1590/S0102-86502011000400012

来源: SciELO

【 摘 要 】

PURPOSE: To assess the viability of McFarlane skin flaps in rats with administration of sildenafil. METHODS: Twenty Wistar rats were distributed into two groups: Control (dorsal skin flap, subdermal application of saline solution at 0.9%) and Study (dorsal skin flap, subdermal application of sildenafil). Seven days after the surgery, flaps were photographed and graphically rendered. Then, they were analyzed with AutoCAD software. Three biopsies (proximal, medial and distal) of each flap were collected for histological analysis. RESULTS: Macroscopic analysis showed that animals of the study group had greater necrotic areas (p=0.003) in the dorsal skin flaps. Additionally, histological analysis of the distal third of these flaps showed a tendency to less granulated tissue formation in animals treated with sildenafil. CONCLUSION: Sildenafil subdermally was associated with lower viability of the random skin flap in rats.

【 授权许可】

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