Grape extract and α-Tocopherol effect in cardiovascular disease model of Apo E -/- Mice

Acta Cirurgica Brasileira

Maria Do Carmo Gouveia Peluzio²  Tatiana Fiche Salles Teixeira²  Vanessa Patrocínio Oliveira²  Céphora Maria Sabarense¹  Cristina Maria Ganz Chaves Dias¹  Monise Viana Abranches¹  Izabel Regina Dos Santos Costa Maldonado¹ 

[1] ,UFV Department of Nutrition and Health Viçosa MG ,Brazil

关键词: Cholesterol;    LDL;    Vitis;    alpha-Tocopherol;    Diet;    Atherogenic;    Mice;    Colesterol LDL;    Vitis;    alfa-Tocoferol;    Dieta Aterogênica;    Camundongos;   

DOI  :  10.1590/S0102-86502011000400002

来源: SciELO

【 摘 要 】

PURPOSE: To verify the effect of consumption of grape extract isolated or combined with α-tocopherol supplementation on atherosclerosis model with Apo E -/- mice. METHODS: After six weeks of atherogenic diet, Apo E -/- mice were divided into the following groups: Control, Grape, Tocopherol and Grape plus Tocopherol. The treatment progressed for 11 weeks when animals were submitted to euthanasia. RESULTS: All the treatments presented hypocholesterolemic effect with reduction of serum and liver cholesterol levels. This effect was parallel to an increase in the fecal excretion of cholesterol. There was also a higher fecal excretion of saturated fatty acids in groups receiving grape extract or α-tocopherol. All the groups treated presented a tendency to show higher levels of vitamin E. The fatty acid profile showed a tendency for monounsaturated fatty acid preservation after grape extract and α-tocopherol consumption. Morphological analysis revealed a lower degree of evolution of the atherosclerotic plaque of the animals that were fed α-tocopherol combined with grape extract, even when no difference was found in the size of the largest lesion. CONCLUSION: A synergistic effect between the polyphenols and α-tocopherol was observed, resulting in diminished evolution of atherosclerosis and a greater beneficial effect on atherosclerosis than the isolated consumption of antioxidants.

【 授权许可】

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