Experimental model of traumatic ulcer in the cheek mucosa of rats

Acta Cirurgica Brasileira

Galyléia Meneses Cavalcante²  Renata Janaína Sousa De Paula²  Leonardo Peres De Souza¹  Fabrício Bitu Sousa¹  Mário Rogério Lima Mota¹  Ana Paula Negreiros Nunes Alves¹ 

[1] ,UFC Ceara ,Brazil

关键词: Ulcer;    Mouth Mucosa;    Wound Heling;    Rats;    Úlcera;    Mucosa Bucal;    Cicatrização de Feridas;    Ratos;   

DOI  :  10.1590/S0102-86502011000300012

来源: SciELO

【 摘 要 】

PURPOSE: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. METHODS: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a nº 15 scalpel blade. The animals were observed for 10 days, during which they were weighed and their ulcers were measured. The histological characteristics were analyzed and scored according to the ulcer phase. In the statistical analysis, a value of p<0.01 was considered a statistically significant response in all cases. RESULTS: During the five first days, the animals lost weight (Student t test, p<0.01). The ulcerated area receded linearly over time and was almost completely cicatrized after 10 days (ANOVA, Tendency posttest, p<0.0001). Groups on days 1, 2 and 3 days displayed similar results, but a decrease in scores were observed after the 4th day. CONCLUSION: The proposed cheek mucosa ulcer model in rats can be considered an efficient, low-cost, reliable, and reproducible method.

【 授权许可】

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