End-to-side nerve repair using fibrin glue in rats

Acta Cirurgica Brasileira

Daniel Nunes E Silva²  Julice Coelho¹  Fabrício De Oliveira Frazílio¹  Alexandre Nakao Odashiro¹  Paulo De Tarso Camillo De Carvalho¹  Elenir Rose Jardim Cury Pontes¹  André Ferrão Vargas¹  Marcelo Rosseto¹  Andréia Brochado Antoniolli Da Silva¹ 

[1] ,University for the State and Pantanal Region Development Department of Medicine Campo Grande,Brazil

关键词: Suture Techniques;    Fibrin Tissue Adhesive;    Microsurgery;    Rats;    Técnicas de Sutura;    Adesivo Tecidual de Fibrina;    Microcirurgia;    Ratos;   

DOI  :  10.1590/S0102-86502010000200007

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate axonal regeneration after end-to-side nerve repair with fibrin glue in rats. METHODS: Forty-five Wistar rats were divided into three groups: group A (n=15), were not submitted to surgery (control group); group B (n=15) were submitted to fibular transection without repair; and group C (n=15), were submitted to fibular transection with end-to-side nerve anastomosis using fibrin glue, in the lateral surface of an intact tibial nerve. The three groups were submitted to walking track (30 and 90 days) and posterior morphometrical analysis (90 days). RESULTS: The functional tests demonstrated that there was no difference in the walking track during the study in group A (p>0.05). The group B had walking pattern impairment in the two tests (p>0.05). The group C had walking pattern impairment in the first test, with important recovery in the second test (p<0.05). The morphometrical assessment revealed significantly higher number of regenerated mielinates axons in group C, compared to group B (p<0.05). CONCLUSION: The end-to-side nerve repair with fibrin glue shows axonal recovery, demonstrated through functional and morphometrical ways in rats.

【 授权许可】

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