Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats

Acta Cirurgica Brasileira

Amália Cínthia Meneses Do Rêgo²  Irami Araújo-filho¹  Ítalo Medeiros Azevedo¹  Daniel Tôrres Jácome¹  Rachel De Alcântara Oliveira Ramalho¹  Aldo Cunha Medeiros¹ 

[1],UFRNNatal,Brazil

关键词: Biological Availability;    Bariatric Surgery;    Sodium Pertechnetate Tc 99m;    Radiopharmaceuticals;    Rats;    Disponibilidade Biológica;    Cirurgia Bariátrica;    Pertecnetato Tc 99m de Sódio;    Compostos Radiofarmacêuticos;    Ratos;   

DOI  :  10.1590/S0102-86502010000100004

来源: SciELO

【 摘 要 】

PURPOSE: The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na99mTc-) in organs and tissues of rats. METHODS: Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1mL of Na99mTc- via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as significant. RESULTS: Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals, compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two groups. CONCLUSION: This work contributes to the knowledge that the bariatric surgery RYGB modifies the pattern of biodistribution of Na99mTc-.

【 授权许可】

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