Acta Cirurgica Brasileira | |
Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines | |
Artur Udelsmann2  William Adalberto Silva1  Ana Cristina De Moraes1  Elisabeth Dreyer1  | |
[1] ,UNICAMP Department of Anesthesiology and Laboratory of Experimental AnesthesiaSao Paulo ,Brazil | |
关键词: Poisoning; Hemodynamics; Anesthetics; Local; Swine; Envenenamento; Hemodinâmica; Anestésicos Locais; Suínos; | |
DOI : 10.1590/S0102-86502009000400009 | |
来源: SciELO | |
【 摘 要 】
PURPOSE: To compare the hemodynamic effects following a toxic dose of either agent after intravenous injection in swines, as might accidentally occur during regional anesthesia in humans. METHODS: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization. After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus intravenous injection of 4 mg.kg-1 of either agent. Hemodynamic results were evaluated at rest and 1, 5, 10, 15, 20 and 30 minutes after intoxication. RESULTS: Hemodynamic repressions of acute intoxication with levobupivacaine were more important and more prolonged than those of ropivacaína. CONCLUSION: In pigs, levobupivacaine was shown to be more toxic than ropivacaine when the same large doses are injected intravenously.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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