Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines

Acta Cirurgica Brasileira

Artur Udelsmann²  William Adalberto Silva¹  Ana Cristina De Moraes¹  Elisabeth Dreyer¹ 

[1] ,UNICAMP Department of Anesthesiology and Laboratory of Experimental AnesthesiaSao Paulo ,Brazil

关键词: Poisoning;    Hemodynamics;    Anesthetics;    Local;    Swine;    Envenenamento;    Hemodinâmica;    Anestésicos Locais;    Suínos;   

DOI  :  10.1590/S0102-86502009000400009

来源: SciELO

【 摘 要 】

PURPOSE: To compare the hemodynamic effects following a toxic dose of either agent after intravenous injection in swines, as might accidentally occur during regional anesthesia in humans. METHODS: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization. After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus intravenous injection of 4 mg.kg-1 of either agent. Hemodynamic results were evaluated at rest and 1, 5, 10, 15, 20 and 30 minutes after intoxication. RESULTS: Hemodynamic repressions of acute intoxication with levobupivacaine were more important and more prolonged than those of ropivacaína. CONCLUSION: In pigs, levobupivacaine was shown to be more toxic than ropivacaine when the same large doses are injected intravenously.

【 授权许可】

CC BY   
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