Acta Cirurgica Brasileira | |
Nicotine on rat TRAM flap | |
Pedro Bins Ely2  Ludmila Aimi Kobayashi1  José Humberto Oliveira Campos1  Heitor Carvalho Gomes1  Yara Juliano1  Lydia Masako Ferreira1  | |
[1] ,Unit Santa Casa de Porto Alegre Plastic Surgery Rio Grande do Sul,Brazil | |
关键词: Surgical Flaps; Nicotine; Rectus Abdominis; Surgery; Plastic; Rats; Retalhos Cirúrgicos; Nicotina; Reto do Abdome; Cirurgia Plástica; Ratos; | |
DOI : 10.1590/S0102-86502009000300010 | |
来源: SciELO | |
【 摘 要 】
PURPOSE: The transverse rectus abdominis myocutaneous (TRAM) flap is one of the preferential techniques used in breast reconstruction following mastectomy. Nicotine has a detrimental effect on cutaneous flap survival; although there are no experimental studies proving this effect on musculocutaneous flaps. The aim of this study is to verify the effect of nicotine on the rat TRAM flap. METHODS: 30 Wistar EPM-1 rats were randomly distributed in two groups: control and experimental. The animals of the control group received saline solution injected subcutaneously, in a volume of 0.2 ml, twice a day, during 28 days in the preoperative period. The animals of the experimental group were treated with nicotine, injected subcutaneously, in a dose of 2 mg/kg twice a day, during 28 days in the preoperative period. All the animals were submitted to the caudally based, right unipedicled TRAM flap. 48 hours after the procedure, a study of the viable area of the flap was done through photographic documentation. Statistical analysis was performed with nonparametric Mann-Whitney's test. RESULTS: The experimental group had significantly greater area of necrosis when compared with the control group (p<0.001). CONCLUSION: Nicotine increased the area of necrosis of the TRAM flap, in rats.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202005130100358ZK.pdf | 671KB | download |